ABNORMAL VASCULAR REACTIVITY IN THE ob/ob MOUSE
نویسندگان
چکیده
منابع مشابه
Abnormal vascular reactivity in growth hormone deficiency.
BACKGROUND The reason why patients with growth hormone (GH) deficiency (GHD) are at increased risk for premature cardiovascular death is still unclear. Although a variety of vascular risk factors have been identified in GHD, little is known regarding vascular reactivity and its contribution to premature arteriosclerosis. METHODS AND RESULTS We assessed vascular function in 7 childhood-onset, ...
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OBJECTIVE The signalling mechanisms involved in regulating altered vascular reactivity in diabetes are not fully understood. The aim of this study was to investigate the role of Ras-GTPase in the development of abnormal vascular reactivity in diabetes. MATERIALS AND METHODS We investigated the ability of chronic administration of FPTIII (1.5 mg/kg), an inhibitor of Ras-GTPase, to modulate the...
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Most vaso-reactive studies in mouse aortic segments are performed in isometric conditions and at an optimal preload, which is the preload corresponding to a maximal contraction by non-receptor or receptor-mediated stimulation. In general, this optimal preload ranges from about 1.2 to 8.0 mN/mm, which according to Laplace's law roughly correlates with transmural pressures of 10-65 mmHg. For phys...
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ژورنال
عنوان ژورنال: Anesthesiology
سال: 2000
ISSN: 0003-3022
DOI: 10.1097/00000542-2000090002-00004